HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholestan-26-oic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholestan-26-oic acid | HCID 122312 | — |
| Reactant | Cannabigerolic Acid | HCID 6449999 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholestan-26-oic acid | HCID 122312 | — |
| Product | Cannabichromenate | HCID 54740355 | — |
Reaction Steps
Table 6 below shows that DMSO, DMF, IPA and cyclodextrin facilitated solubilization of cannabinoids. Cyclodextrin solubilized up to 20-25 g/L of CBGA for conversion. Enzymatic rate was enhanced when 20% DMSO (v/v) was added to the reaction mixture and THCA synthase produced both THCA and CBCA in the reaction (Table 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394510B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-acf522adba094ecc8137c9cf4756d3d2 |
| Source note | uspto-grants-2016_07 |