5-Bromo-2-chlorobenzoyl chloride → HCID 86685116, compound

Participants

Reaction Steps

To a solution of 5-bromo-2-chlorobenzoyl chloride 21d (3.41 g, 13.4 mmol) and 1-ethoxy-2,3-difluoro-benzene 23b (2.42 g, 15.2 mmol) in dichloromethane (50 mL) was added anhydrous aluminium chloride (1.82 g, 13.7 mmol) in portions over 1 hours at 0° C. The mixture was stirred at room temperature for 16 hours. The reaction mixture was quenched with hydrochloric acid (10 mL, 2 M) and extracted with dichloromethane (40 mL×4). The combined layers were dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to give the title compound 23d as yellow oil (5.03 g, 100%). This material was not further purified.

Provenance & Evidence