1,2-Dichlorobenzene → HCID 118391137, compound

Participants

Reaction Steps

To a solution of 2-[(1S,2S,3S,4R,5S)-2,3,4-tribenzyloxy-5-[3-[(4-benzyloxyphenyl)methyl]-4-chloro-phenyl]-6,8-dioxabicyclo[3.2.1]octan-1-yl]propan-2-ol 25o (100 mg, 0.12 mmol) in a methanol/tetrahydrofuran mixture (v/v=4/1, 10 mL) were added o-dichlorobenzene (0.07 mL, 0.63 mmol) and 10% Pd/C (20 mg, 0.02 mmol) at room temperature. The mixture was stirred under H2 at room temperature for 4 hours and filtered. The filtrate was concentrated in vacuo to give the title compound 25p as a white solid (54.8 mg, 100%). The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 481.0[M+HCOO]−.

Provenance & Evidence