HuagongsheHuagongshe Chemistry Print Report · For research reference only
Uracil → 5-Iodouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Uracil | HCID 1174 | — |
| Reactant | (5-Iodo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetic acid | HCID 1361763 | — |
| Reactant | HCID 57253309 | HCID 57253309 | — |
| Product | 5-Iodouracil | HCID 69672 | — |
Reaction Steps
The PNA trimer can be synthesized manually or in an automated peptide synthesizer. The synthesis of universal base PNA monomer has been reported in the literature129,130 The modified uracil PNA monomer may be synthesized starting from 5-iodouracil-1-acetic acid.131 The starting material reacts with ethyl N-[2-Boc-aminoethyl]glycinate, providing a 5-iodouracil PNA monomer that can be converted into the desired product through the Sonogashira coupling132 with 3-benzoylthio-1-propyne followed by treating with di-tbutyl-1-(tbutylthio)hydrazine-1,2-dicarboxylate.34
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09395352B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-a69cfa82f3f64dcfbab481e5f1e4a4f6 |
| Source note | uspto-grants-2016_07 |