Hydrochloric Acid → 1289124-26-0

Participants

Reaction Steps

0.38 g (1.7 mmol) of methyl 3-tert-butyl-5-formylbenzoate [for the preparation, see, for example, WO 2008/089034-A2, intermediate K/step 1] were initially charged in 20 ml of water, 0.5 g of lithium hydroxide monohydrate were added and the mixture was stirred at RT for 1 h. The reaction solution was then adjusted to pH 2 with 1 M hydrochloric acid and extracted with ethyl acetate. The organic phase was dried over sodium sulphate, filtered and concentrated on a rotary evaporator. This gave 0.31 g (87% of theory) of the title compound.

Provenance & Evidence