Cesium carbonate → HCID 89699709, compound

Participants

Reaction Steps

150 mg (0.57 mmol) of the compound of Example 24A, 140 mg (0.63 mmol) of tert-butyl-(2-bromoethyl)carbamate and 388 mg (1.2 mmol) of caesium carbonate were initially charged in 1.5 ml of DMF and stirred at RT overnight. 1.7 ml of 1 M aqueous sodium hydroxide solution were then added, and the mixture was stirred at RT for another 1 h. The reaction mixture was then acidified slightly with concentrated acetic acid and purified directly by preparative HPLC (Method 18). This gave 63 mg (26% of theory) of the title compound.

Provenance & Evidence