Potassium Carbonate → HCID 89700053, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 250 mg (0.764 mmol) of the compound of Example 15A, 86 mg (0.841 mmol) of sodium methanesulphinate, 19 mg (0.168 mmol) of (S)-proline and 23 mg (0.168 mmol) of potassium carbonate in 3 ml of DMSO/water (4:1) was initially degassed, 16 mg (0.084 mmol) of copper(I) iodide were then added and the mixture was finally, under an argon atmosphere, heated in a microwave oven (Biotage Initiator, with Dynamic Field Tuning) at 150° C. for 30 min. After cooling to RT, the reaction mixture was filtered through a little Celite and then separated into its components by preparative HPLC (Method 9). Concentration of the product fractions and drying of the residue under high vacuum gave 83 mg (33% of theory) of the title compound.

Provenance & Evidence