Sodium Hydroxide → N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(4-methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

Participants

Reaction Steps

70 mg (0.14 mmol) of the compound of Example 8A, 62.9 mg (0.14 mmol) of the compound of Example 17A and 62 mg (0.16 mmol) of HATU were dissolved in 0.79 ml of DMF, 0.07 ml (0.41 mmol) of N,N-diisopropylethylamine were added and the mixture was stirred at RT for 1 h. The mixture was then stirred into 10 ml of 0.1 M aqueous sodium hydroxide solution and stirred at RT for 10 min, and the precipitate formed was then filtered off. The solid was washed with water and dried under high vacuum. This gave 94 mg (94% pure, 89% of theory) of the title compound.

Provenance & Evidence