8-Hydroxyquinoline → N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(trifluoromethyl)benzamide

Participants

Reaction Conditions

Reaction Steps

55 mg (0.19 mmol) of the compound of Example 5A and 74 mg (0.21 mmol) of the compound of Example 45A were dissolved in 1.24 ml of DMF and 0.12 ml of water, and 126 mg (0.39 mmol) of bis(tetraethylammonium) carbonate were added carefully. The mixture was degassed with argon, and 14.3 mg (0.08 mmol) of copper(I) iodide and 10.9 mg (0.08 mmol) of 8-hydroxyquinoline were then added. The reaction was then heated in a microwave oven (Biotage Initiator, with Dynamic Field Tuning) at 160° C. for 1 h. After cooling, the mixture was poured into 10 ml of water and extracted with ethyl acetate. The organic phase was washed with saturated sodium chloride solution and concentrated under reduced pressure. The residue was purified by preparative HPLC (Method 11). The product fractions were concentrated and the residue was dried under high vacuum. This gave 26 mg (57% pure, 14% of theory) of the title compound which was reacted further in this form.

Provenance & Evidence