1-Bromo-2,4-dimethyl-5-nitrobenzene → 1-(2,2-Diethoxyethyl)-N-(2,4-dimethyl-5-nitrophenyl)-3-(pyrimidin-5-yl)-1H-pyrazole-5-amine

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Reaction Steps

Analogously to Example 13A/Step 1, 3.01 g (10.8 mmol) of the compound of Example 78A and 2.75 g (11.9 mmol) of 5-bromo-2,4-dimethylnitrobenzene gave, after 3 h of heating under reflux, a crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol). This gave 3.70 g (65% of theory) of the title compound.

Provenance & Evidence