2-Bromo-4-nitrotoluene → HCID 89699896, compound

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Reaction Steps

Analogously to Example 13A/Step 1, 4.5 g (16.2 mmol) of the compound of Example 79A and 3.86 g (17.8 mmol) of 2-bromo-4-nitrotoluene gave, after 3 h of heating under reflux, a crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol). This gave 5.52 g (82% of theory) of the title compound.

Provenance & Evidence