反应详情

Analogously to Example 13A/Step 1, 1.09 g (3.93 mmol) of the compound of Example 80A and 996 mg (4.33 mmol) of 5-bromo-2,4-dimethylnitrobenzene gave, after 3 h of heating under reflux, a crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol). This gave 1.38 g (77% of theory) of the title compound.

1. customgave, after 3 h
2. temperatureof heating
3. temperatureunder reflux
4. customa crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol)