Trifluoroacetic acid → HCID 86690980, compound

Participants

Reaction Steps

40 mg (0.14 mmol) of the compound of Example 6A and 62 mg (0.15 mmol) of the compound of Example 29A were reacted and worked up analogously to the procedure of Example 16. In this manner, 81 mg (86% of theory) of the Boc-protected intermediate tert-butyl {2-[3-({4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenoxy]ethyl}carbamate were obtained. This compound was stirred in 1 ml of dichloromethane and 0.5 ml of trifluoroacetic acid at RT for 2 h. The mixture was then concentrated under reduced pressure and the residue was purified by preparative HPLC (Method 18). The product-containing fractions were combined and concentrated under reduced pressure, and the residue was dissolved in ethyl acetate and washed successively with saturated potassium carbonate solution and saturated sodium chloride solution. The organic phase was dried over sodium sulphate, filtered and concentrated under reduced pressure. Drying of the residue gave 61 mg (76% of theory) of the title compound.

Provenance & Evidence