HCID 66523456, compound → HCID 89699913, compound

HRID 1055723Notes

Reaction equation

HRID 1055723 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[Cl:23][C:24]1[CH:25]=[C:26]([CH:30]=[C:31]([S:33]([F:38])([F:37])([F:36])([F:35])[F:34])[CH:32]=1)[C:27](O)=[O:28]>>[Cl:23][C:24]1[CH:25]=[C:26]([CH:30]=[C:31]([S:33]([F:38])([F:34])([F:35])([F:36])[F:37])[CH:32]=1)[C:27]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:28]

Participants

3

Reactant 2

HCID 66523456HCID 66523456, compoundHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Product 1

HCID 89699913HCID 89699913, compound

Procedure

Analogously to the process described in Example 26, 80 mg (0.276 mmol) of the compound of Example 6A and 78 mg (0.276 mmol) of the compound of Example 33A gave 101 mg (66% of theory) of the title compound.

Sources & evidence

ORD record
ord-260d2cb390424b54aead81bb33817d6b
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

Loading…