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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1055731Generated: November 2, 2026

3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzoic acid → 3-(2-Methyl-1H-imidazol-1-yl)-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(trifluoromethyl)benzamide

https://huagongshe.com/reaction/1055731

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzoic acidHCID 67214325—
Reactant4-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]anilineHCID 89700023—
Product3-(2-Methyl-1H-imidazol-1-yl)-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(trifluoromethyl)benzamideHCID 89699711—

Reaction Steps

35 mg (0.12 mmol) of the compound of Example 6A and 33 mg (0.12 mmol) of 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid [lit.: WO 2004/005281 A1, Example 91b] were reacted and worked up analogously to the procedure of Example 16. This gave 53 mg (81% of theory) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09394309B2
Source datasetuspto-grants-2016_07
ORD IDord-c8d80b30bba24c868ed9c3a223b1ef7f
Source noteuspto-grants-2016_07