HCID 46738290, compound → HCID 89700219, compound

HRID 1055732Notes

Reaction equation

HRID 1055732 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:30]2[CH:31]=[C:32]([CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=2)[C:33](O)=[O:34])[CH2:26][CH2:25]1>>[CH3:23][N:24]1[CH2:25][CH2:26][N:27]([C:30]2[CH:31]=[C:32]([CH:36]=[C:37]([C:39]([F:42])([F:40])[F:41])[CH:38]=2)[C:33]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]3[C:16]4[N:12]([N:13]=[C:14]([C:17]5[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=5)[CH:15]=4)[CH:11]=[CH:10]3)[CH:4]=2)=[O:34])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 46738290HCID 46738290, compoundHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Product 1

HCID 89700219HCID 89700219, compound

Procedure

40 mg (0.14 mmol) of the compound of Example 6A and 44 mg (0.14 mmol) of 3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzoic acid [lit.: WO 2004/029038-A1, Example 14.2] were reacted and worked up analogously to the procedure of Example 33. This gave 43 mg (53% of theory) of the title compound.

Sources & evidence

ORD record
ord-85cd4e463b15471b9617fcda164f8eb6
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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