HCID 66523461, compound → HCID 89700288, compound

HRID 1055749Notes

Reaction equation

HRID 1055749 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[F:23][C:24]1[CH:25]=[C:26]([CH:30]=[C:31]([S:33]([F:38])([F:37])([F:36])([F:35])[F:34])[CH:32]=1)[C:27](O)=[O:28]>>[F:23][C:24]1[CH:25]=[C:26]([CH:30]=[C:31]([S:33]([F:38])([F:34])([F:35])([F:36])[F:37])[CH:32]=1)[C:27]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:28]

Participants

3

Reactant 2

HCID 66523461HCID 66523461, compoundHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Product 1

HCID 89700288HCID 89700288, compound

Procedure

Analogously to the process described in Example 26, 100 mg (0.346 mmol) of the compound of Example 6A and 97 mg (0.363 mmol) of 3-fluoro-5-(pentafluoro-λ6-sulphanyl)benzoic acid (JRD Fluorochemicals Ltd., United Kingdom) gave 165 mg (89% of theory) of the title compound. In this case, the reaction time was about 15 h.

Sources & evidence

ORD record
ord-5cc92b56ffa743499a018684eb3b1473
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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