Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 89699459, compound

Participants

Reaction Conditions

Reaction Steps

394 mg (1.04 mmol) of HATU and 127 mg (1.04 mmol) of 4-N,N-dimethylaminopyridine (DMAP) were added to a solution of 200 mg (0.69 mmol) of the compound of Example 6A and 288 mg (1.04 mmol) of 2-methoxy-5-(pentafluoro-λ6-sulphanyl)benzoic acid in 2.2 ml of DMF. The reaction was stirred at 50° C. for 16 h. The reaction mixture was then purified directly by preparative HPLC (Method 16). This gave 222 mg (53% of theory) of the title compound.

Provenance & Evidence