Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → N-{2,4-Dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(methoxymethyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

Participants

Reaction Steps

75 mg (0.198 mmol) of HATU, 24 mg (0.198 mmol) of 4-N,N-dimethylaminopyridine (DMAP) and 50 mg (0.165 mmol) of the compound of Example 11A were added to a solution of 51 mg (0.173 mmol) of the compound of Example 74A in 1 ml of anhydrous DMF. The reaction mixture was stirred at RT for 1 h, then diluted with about 2 ml of methanol and subsequently directly separated into its components by preparative HPLC (Method 32). Evaporation of the product fractions and drying of the residue under high vacuum gave 60 mg (63% of theory) of the title compound.

Provenance & Evidence