HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pentafluorosulfanyl)benzoic acid → HCID 71667104, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pentafluorosulfanyl)benzoic acid | HCID 2779209 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 89699621 | HCID 89699621 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71667104 | HCID 71667104 | — |
Reaction Steps
193 mg (0.51 mmol) of HATU and 62 mg (0.51 mmol) of 4-N,N-dimethylaminopyridine (DMAP) were added to a solution of 100 mg (0.34 mmol) of the compound of Example 89A and 92 mg (0.37 mmol) of 3-(pentafluoro-λ6-sulphanyl)benzoic acid in 2 ml of DMF. The reaction was stirred at RT for 20 h. The reaction mixture was then purified directly by preparative HPLC (Method 16). This gave 50.2 mg (27% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394309B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-c9d910dea1594737b8df4721260c0de5 |
| Source note | uspto-grants-2016_07 |