反应详情

This compound (0.71 g, 63% yield) as a yellow crystalline solid was prepared according to the procedure described for intermediate 711, using 2-chloro-8-iodo-3-methylquinazolin-4(3H)-one (700) (0.96 g, mmol), 2-fluoro-1,1-dimethyl-ethylamine hydrochloride (AmfineCom Inc; 0.69 g, 5.40 mmol) (AmfineCom Inc.) and TEA (2.1 mL, 15.10 mmol) as the starting materials. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.16 (1H, d, J=7.2 Hz), 7.96 (1H, d, J=7.4 Hz), 6.95 (1H, t, J=7.6 Hz), 6.16 (1H, br.), 5.04 (1H, s), 4.92 (1H, s), 3.47 (3H, s), 1.58 (6H, s). m/z (ESI, +ve) 375.8 (M+1-1)′).