2-(tert-butylamino)-8-iodo-3-(2-methoxyethyl)quinazolin-4(3H)-one → 2-(tert-butylamino)-8-iodo-3-(2-(2-methoxy-ethoxy)ethyl)quinazolin-4(3H)-one

Participants

Reaction Steps

This compound (0.33 g, 0.74 mmol) was prepared according to the procedures described for Intermediate 715, starting from 8-iodo-3-(2-(2-methoxyethoxyl)ethyl)-2-(methylthio)quinazolin-4(3H)-one (716b; 0.79 g, 1.87 mmol). 1H NMR (400 MHz, CDCl3) δ ppm 8.08 (ddd, J=14.43, 7.68, 1.56 Hz, 2H), 6.84 (t, J=7.73 Hz, 1H), 6.20 (s, 1H), 4.19-4.25 (m, 2H), 3.81-3.86 (m, 2H), 3.60-3.65 (m, 2H), 3.51-3.56 (m, 2H), 3.35 (s, 3H), 1.61 (s, 9H). m/z (ESI, +ve ion) 446.0 (M+H)+.

Provenance & Evidence