Methanimidamide, hydrochloride (1:1) → HCID 136500838, compound

Participants

Reaction Conditions

Reaction Steps

Formamidine hydrochloride (0.296 g, 3.67 mmol) and ethyl 2-amino-5-(2-chloroquinolin-8-yl)-1H-pyrrole-3-carboxylate (0.232 g, 0.735 mmol) were combined in 3 mL IPA, sealed, and heated to 100° C. overnight. An additional 1 mL IPA was added, and the reaction resealed and heated to 110° C. for 24 additional hours. The reaction was cooled, diluted with IPA, and filtered, rinsing 2×IPA. The solid was collected and dried in vacuo to give 6-(2-chloroquinolin-8-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one hydrochloride (0.218 g, 0.654 mmol, 89% yield): 1H NMR (400 MHz, DMSO-d6) δ ppm 12.34 (1H, br. s.), 8.53 (1H, d, J=8.6 Hz), 8.23-8.30 (1H, m), 8.00 (1H, dd, J=7.9, 1.1 Hz), 7.92 (1H, s), 7.66-7.77 (2H, m), 7.49 (1H, s), 7.01-7.26 (2H, m). m/z (ESI, +ve) 296.9 (M+H)+.

Provenance & Evidence