N-Methylisopropylamine → HCID 89783957, compound

Participants

Reaction Conditions

Reaction Steps

Prepared according to Example 127, using 2-(3-fluoro-2-methylquinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (Example 126; 40 mg, 0.135 mmol), N-methylpropan-2-amine (29.6 mg, 0.405 mmol, Sigma Aldrich), and DMSO (1.4 mL) and stirring at 80° C. for 2 h. Purification by high throughput parallel purification (Rilas Technologies, Woburn, Mass.) provided 2-(2-methyl-3-(methyl(1-methylethyl)amino)-5-quinoxalinyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one. 1H NMR (DMSO-d6) δ: 11.87 (br. s, 1H), 7.86-7.93 (m, 1H), 7.59-7.68 (m, 1H), 7.39-7.50 (m, 1H), 7.17 (s, 1H), 6.95 (br. s, 1H), 4.16-4.28 (m, 1H), 3.38-3.46 (m, 2H), 2.82-2.89 (m, 2H), 2.66 (s, 3H), 2.55 (s, 3H), 1.22-1.28 (m, 6H). m/z (ESI, +ve) 350.1 (M+H)+.

Provenance & Evidence