1,2-Dimethylpropylamine → HCID 89783661, compound

Participants

Reaction Conditions

Reaction Steps

Prepared according to Example 127, using 2-(3-fluoro-2-methylquinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (Example 126; 40 mg, 0.135 mmol), rac-3-methylbutan-2-amine (35.3 mg, 0.405 mmol, Sigma Aldrich), and DMSO (1.4 mL) stirring at 80° C. for 2 h. Purification by high throughput parallel purification (Rilas Technologies, Woburn, Mass.) provided 2-(3-(((±)-1,2-dimethylpropyl)amino)-2-methyl-5-quinoxalinyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one. 1H NMR (DMSO-d6) δ: 11.95-12.11 (m, 1H), 7.81-7.91 (m, 1H), 7.49-7.67 (m, 1H), 7.26-7.37 (m, 1H), 7.08-7.21 (m, 1H), 6.86-7.02 (m, 1H), 6.65-6.84 (m, 1H), 4.01-4.20 (m, 1H), 3.38-3.50 (m, 2H), 2.84-2.96 (m, 2H), 2.58 (s, 3H), 1.98-2.13 (m, 1H), 1.21-1.34 (m, 3H), 0.93-1.12 (m, 6H). m/z (ESI, +ve) 364.1 (M+H)+.

Provenance & Evidence