Diisopropylethylamine → 8-bromo-3-methyl-N-(1-methylcyclopropyl)quinoxalin-2-amine

関与物質

反応手順

This compound (0.50 g, 45% yield) as a light yellow crystalline solid was prepared according to Example 174, using 5-bromo-3-fluoro-2-methylquinoxaline (126f; 0.96 g, 3.72 mmol), 1-methylcyclopropanamine hydrochloride (ChemBridge, San Diego, Calif.; 0.6 g, 5.58 mmol), and DIPEA (2.59 mL, 14.87 mmol) as starting materials: 1H NMR (400 MHz, DMSO-d6) δ ppm 7.83 (dd, J=7.6, 1.2 Hz, 1H), 7.71 (dd, J=8.2, 1.2 Hz, 1H), 7.45-7.51 (m, 1H), 7.22 (t, J=7.8 Hz, 1H), 2.47 (s, 3H), 1.54 (s, 3H), 0.78-0.84 (m, 2H), 0.68-0.75 (m, 2H). m/z (ESI, +ve) 292/294 (M+H)+.

情報源と証拠