Trifluoroacetic acid → HCID 118512000, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-tert-butyl 3-((8-(4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl)quinolin-2-yl)amino)piperidine-1-carboxylate (78.0 mg, 0.169 mmol) and TFA (0.30 mL, 3.894 mmol) in DCM (1.5 mL) was stirred at 25° C. for 1 h. The mixture was concentrated in vacuo, and the residue was taken up in DMSO (2.0 mL) and purified by reversed-phase HPLC (Phenomenex Gemini C18 column (150×30 mm, 10 μm), 35 mL/min, 5-100% ACN/H2O+0.1% TFA) to provide (S)-2-(2-(piperidin-3-ylamino)quinolin-8-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one 2,2,2-trifluoroacetate (41.1 mg, 0.086 mmol, 51% yield) as a yellow-orange solid: 1H NMR (400 MHz, MeOH-d4) δ ppm 8.16 (1H, br. s.), 7.84 (1H, dd, J=7.5, 1.1 Hz), 7.69 (1H, d, J=7.6 Hz), 7.35-7.46 (1H, m), 7.25-7.34 (1H, m), 6.97-7.09 (1H, m), 4.33-4.45 (1H, m), 3.74 (1H, dd, J=12.3, 3.3 Hz), 3.64 (2H, t, J=7.1 Hz), 3.41 (1H, dt, J=12.7, 3.8 Hz), 3.04-3.16 (2H, m), 3.01 (2H, t, J=7.0 Hz), 2.26-2.35 (1H, m), 2.08-2.19 (1H, m), 1.90-2.04 (1H, m), 1.70-1.84 (1H, m). 19F NMR (377 MHz, MeOH-d4) δ ppm −77.49 (3F, s). m/z (ESI, +ve) 362.3 (M+H)+.

Provenance & Evidence