Diisopropylethylamine → HCID 71731020, compound

Participants

Reaction Conditions

Reaction Steps

Prepared similarly to that described in Example 131 using 2-(3-fluoro-2-methylquinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (Example 126; 48 mg, 0.162 mmol), 1-methylcyclopropanamine hydrochloride (34.9 mg, 0.324 mmol, ChemBridge, San Diego, Calif.), and DIPEA (141 μl, 0.810 mmol), heating at 100° C. for 2 h. Purification by silica gel (100% DCM to 6% MeOH/DCM) provided 2-(2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (25% yield). 1H NMR (400 MHz, MeOH-d4) δ ppm 0.93-1.00 (m, 2H) 1.01-1.07 (m, 2H) 1.66 (s, 3H) 2.53 (s, 3H) 3.03 (t, J=7.04 Hz, 2H) 3.64 (t, J=7.04 Hz, 2H) 7.11 (s, 1H) 7.39 (t, J=7.92 Hz, 1H) 7.61 (d, J=8.02 Hz, 1H) 8.00 (d, J=7.63 Hz, 1H). MS (ESI, pos. ion) m/z: 348.2 (M+1).

Provenance & Evidence