2,2-Dimethylpiperazine → 2-(3-(3,3-dimethylpiperazin-1-yl)quinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one

Participants

Reaction Conditions

Reaction Steps

Prepared similarly to that described in Example 210 using 2-(3-fluoroquinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (Example 210i; 57 mg, 0.202 mmol) and 2,2-dimethylpiperazine (46.1 mg, 0.404 mmol, Chem-Impex International, Wood Dale, Ill.), heating at 60° C. for 1 h. Purification by filtration provided 2-(3-(3,3-dimethylpiperazin-1-yl)quinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (67% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.13 (s, 6H) 2.87 (t, J=6.85 Hz, 2H) 2.92-2.99 (m, 2H) 3.44 (td, J=6.85, 2.15 Hz, 2H) 3.61 (s, 2H) 3.74 (t, J=4.69 Hz, 2H) 6.94 (br. s., 1H) 7.14 (d, J=2.15 Hz, 1H) 7.39 (t, J=7.82 Hz, 1H) 7.66 (d, J=6.85 Hz, 1H) 7.89 (d, J=6.46 Hz, 1H) 8.87 (s, 1H) 11.77 (br. s., 1H). MS (ESI, pos. ion) m/z: 377.1 (M+1).

Provenance & Evidence