1-Boc-3,3-dimethylpiperazine → HCID 89784004, compound

Participants

Reaction Conditions

Reaction Steps

Prepared similarly to that described in Example 210 using 2-(3-fluoroquinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (Example 210i; 100 mg, 0.354 mmol) and tert-butyl 3,3-dimethylpiperazine-1-carboxylate (152 mg, 0.709 mmol), heating at 120° C. for 1 d. Purification by rpHPLC (Phenomenex Gemini C18, 10 μm, 150×30 mm; 10-100% ACN/water with 0.1% TFA) provided tert-butyl 3,3-dimethyl-4-(8-(4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl)quinoxalin-2-yl)piperazine-1-carboxylate (16% yield). MS (ESI, pos. ion) m/z: 477.2 (M+1).

Provenance & Evidence