Trifluoroacetic acid → HCID 89784036, compound

Participants

Reaction Steps

A solution of tert-butyl 3,3-dimethyl-4-(8-(4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl)quinoxalin-2-yl)piperazine-1-carboxylate (27 mg, 0.057 mmol) and TFA (4.36 μl, 0.057 mmol) in DCM (567 μl) was stirred at RT for 20 min. Purification by silica gel (100% DCM to 8% [2 M NH3 in MeOH]/DCM) provided 2-(3-(2,2-dimethylpiperazin-1-yl)quinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (19% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.45 (s, 6H) 2.32-2.35 (m, 1H) 2.66-2.71 (m, 2H) 2.86 (t, J=6.94 Hz, 2H) 2.95-2.99 (m, 1H) 3.44 (td, J=6.75, 2.35 Hz, 2H) 3.60 (t, J=4.9 Hz, 2H) 6.96 (s, 1H) 7.09 (d, J=2.15 Hz, 1H) 7.52 (t, J=7.63 Hz, 1H) 7.73 (d, J=7.04 Hz, 1H) 7.92 (d, J=7.43 Hz, 1H) 8.81 (s, 1H) 11.71 (s, 1H). MS (ESI, pos. ion) m/z: 377.1 (M+1).

Provenance & Evidence