HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1056053Generated: October 25, 2026
Phosphorus oxybromide → 2,8-Dibromoquinoline
https://huagongshe.com/reaction/1056053
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxybromide | HCID 24613 | — |
| Reactant | 8-Bromo-1,2-dihydroquinolin-2-one | HCID 10933094 | — |
| Product | 2,8-Dibromoquinoline | HCID 45925951 | 64% |
Reaction Steps
A mixture of phosphorus oxybromide (1.59 g, 5.55 mmol) and 8-bromo-2(1H)-quinolinone (0.250 g, 1.11 mmol) was heated at 125° C. for 2 h before being poured onto ice. The resulting precipitate was filtered and crystallized from MeOH to give 2,8-dibromo-quinoline (0.2 g, 64%) as colorless prisms. MS (ESI, pos. ion) m/z: 287.8 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09394297B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-6e9d9aa5f6fb4a3eb57a0be875163924 |
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| Source note | uspto-grants-2016_07 |
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