HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid → Ethyl 3-(1-{[(tert-butoxy)carbonyl]amino}cyclopropyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid | HCID 688396 | — |
| Reactant | 4-((tert-Butoxycarbonyl)amino)-3-oxobutanoic acid ethyl ester | HCID 11128564 | — |
| Product | Ethyl 3-(1-{[(tert-butoxy)carbonyl]amino}cyclopropyl)-3-oxopropanoate | HCID 89781999 | — |
Reaction Steps
A tautomeric mixture of ethyl 3-(1-((tert-butoxycarbonyl)amino)cyclopropyl)-3-oxopropanoate and (Z)-ethyl 3-(1-((tert-butoxycarbonyl)amino)cyclopropyl)-3-hydroxyacrylate (3.15 g, 11.61 mmol, 90% yield) as an off white solid was prepared according the procedures described for Intermediate 601, using 1-(Boc-amino)cyclopropanecarboxylic acid (Chem-Impex International, Inc., cat #04052) (2.59 g, 12.87 mmol) as the reagent. m/z (ESI, +ve) 294.2 (M+23)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394297B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-334910615d7444ad96af360f66e96e68 |
| Source note | uspto-grants-2016_07 |