1-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone → 1-(6-Fluoro-3-(isopropylamino)-2-methylquinoxalin-5-yl)ethanone

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Reaction Steps

1-(6-Fluoro-3-(isopropylamino)-2-methylquinoxalin-5-yl)ethanone (619b) (3.58 g, 90% yield) as an orange solid was prepared according to the procedures described for Intermediate 610b, using 8-bromo-7-fluoro-N-isopropyl-3-methylquinoxalin-2-amine (373a) (2.00 g, 6.70 mmol) as the starting material. 19F NMR (377 MHz, DMSO-d6) δ ppm −116.42. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.80 (1H, dd, J=9.0, 6.1 Hz), 7.20 (1H, t, J=9.2 Hz), 7.01 (1H, d, J=7.4 Hz), 4.23 (1H, m), 2.66 (3H, s), 2.52 (3H, s), 1.26 (6H, d, J=6.7 Hz). m/z (ESI, +ve) 262.1 (M+H)+.

Provenance & Evidence