Trifluoroacetic acid → HCID 131736418, compound

Participants

Reaction Conditions

Reaction Steps

An orange solution of (R)-tert-butyl 2-(3-(benzyloxy)-1-((tert-butoxycarbonyl)amino)propyl)-1-tosyl-1H-pyrrole-3-carboxylate (504c, 5.85 g, 10.00 mmol) in DCM (15 mL) was treated with TFA (15 mL, 202 mmol) and heated at 40° C. for 2 h. The TFA and DCM was removed in vacuo affording (R)-2-(1-amino-3-(benzyloxy)propyl)-1-tosyl-1H-pyrrole-3-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1) (724d) as a dark orange viscous oil which was used for the next step without purification. m/z (ESI, +ve) 429.2 (M+1)′.

Provenance & Evidence