Acetic Anhydride → HCID 89783360, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(3-(tert-butylamino)-2-methylquinoxalin-5-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (193) (0.13 g, 0.37 mmol), DMAP (0.45 g, 3.75 mmol), and Ac2O (0.35 mL, 3.75 mmol) in pyridine (2 mL) was stirred at 50° C. in 24h. The reaction mixture was cooled, concentrated to dryness, purified by ISCO (0-30% EtOAc/DCM) to give the title compound (33 mg, 22%). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.11 (1H, br. s.), 7.75-7.88 (1H, m), 7.54-7.67 (1H, m), 7.35 (1H, t, J=7.8 Hz), 7.30 (1H, d, J=2.2 Hz), 6.01 (1H, s), 4.14 (2H, t, J=6.3 Hz), 2.94 (2H, t, J=6.4 Hz), 2.55 (3H, s), 2.44 (3H, s), 1.56 (9H, s). m/z (ESI, +ve) 392.0 (M+H)+.

Provenance & Evidence