HCID 89782033, compound → HCID 89781909, compound

HRID 1056223Notes

Reaction equation

HRID 1056223 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[N:7]=[C:8]([NH:16][C:17]([CH3:20])([CH3:19])[CH3:18])[C:9](F)=[N:10]2)=[O:4].C(NC1C([Cl:39])=NC2C(N=1)=C(C(=O)C)C=CC=2)(C)(C)C>>[Br:1][CH2:2][C:3]([C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[N:7]=[C:8]([NH:16][C:17]([CH3:20])([CH3:19])[CH3:18])[C:9]([Cl:39])=[N:10]2)=[O:4]

Participants

3

Reactant 2

HCID 89782033HCID 89782033, compoundHCID 89782041HCID 89782041, compound

Product 1

HCID 89781909HCID 89781909, compoundYield 59%

Procedure

This compound (215 mg, 59% yield) as a yellow oil was prepared according to the procedures described for intermediate 343c, using 1-(3-(tert-butylamino)-2-chloroquinoxalin-5-yl)ethanone (345a) (285 mg, 1.02 mmol) as the starting material. 1H NMR (400 MHz, CDCl3) δ ppm 1.57 (s, 9H) 4.93 (s, 2H) 5.82 (br. s., 1H) 7.43 (t, J=7.82 Hz, 1H) 7.94 (d, J=7.63 Hz, 2H). MS (ESI, pos. ion) m/z: 356.0/358.0 (M+1).

Sources & evidence

ORD record
ord-2bf74c06596948d093e898ca2a138388
Source dataset
uspto-grants-2016_07
Patent number
US09394297B2

Reaction notes

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