反应详情

This compound (594 mg, 1.99 mmol, 91% yield) as an orange crystalline solid was prepared according to the procedure described for Intermediate 605a, using 5-bromo-3-chloro-6-fluoro-2-methylquinoxaline (600) (600 mg, 2.17 mmol) and isopropylamine (0.94 mL, 10.9 mmol) in DMSO (5.0 mL) as the starting materials. 1H NMR (400 MHz, CDCl3) δ ppm 7.73 (1H, dd, J=9.0, 5.9 Hz), 7.15 (1H, t, J=8.6 Hz), 4.68-4.82 (1H, m), 4.52 (1H, dq, J=13.2, 6.5 Hz), 2.53 (3H, s), 1.39 (6H, d, J=6.5 Hz). 19F NMR (376 MHz, CDCl3) δ ppm −103.43 (1F, s). m/z (ESI, +ve ion) 298.5/300.6 (M+H)+.