Methyl iodide → HCID 89782132, compound

Participants

Reaction Steps

A mixture of 8-bromo-3-(pyridin-2-yl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (330 mg, 0.987 mmol, 415b), K2CO3 (59.6 mg, 0.987 mmol), and THF (9.9 mL) was set stirring under nitrogen at RT. MeI (61.3 pt, 0.987 mmol) was added, and the mixture was set stirring at 75° C. for 4 h. The reaction was cooled to RT and filtered, rinsing with chilled THF. The filtrate was concentrated under reduced pressure to give 310 mg of a waxy yellow-brown solid that contained the product. m/z (ESI, +ve) 349.7 (M+H)+.

Provenance & Evidence