HCID 89781918, compound → HCID 89783472, compound

Participants

Reaction Steps

This compound (66 mg, 31% yield) as a brown solid was prepared according to the procedure described for Example 448, using 8-iodo-3-methyl-2-(1-methylcyclopropoxy)quinazolin-4(3H)-one (717) (210 mg, 0.59 mmol) and (R)-6-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one (705) (201 mg, 0.76 mmol) as the starting materials. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.21 (1H, br.), 8.18 (1H, d, J=7.8 Hz), 7.94 (1H, d, J=7.6 Hz), 7.74 (1H, s), 7.41 (1H, t, J=7.7 Hz), 7.16 (1H, s), 4.65 (1H, d, J=6.5 Hz), 3.36 (3H, S), 1.78 (3H, s), 1.39 (3H, d, J=6.5 Hz), 1.25 (2H, m), 0.94 (2H, m). m/z (ESI, +ve) 365.0 (M+H)+.

Provenance & Evidence