(R)-6-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one → HCID 89783528, compound

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Reaction Steps

This compound (77 mg, 34% yield) as a brown solid was prepared according to the procedure described for Example 448, using 24(1-fluoro-2-methylpropan-2-yl)amino)-8-iodo-3-methylquinazolin-4(3H)-one (712) (221 mg, 0.59 mmol) and (R)-6-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one (705) (193 mg, 0.74 mmol) as the starting materials. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.63 (1H, br.), 7.94 (1H, d, J=7.4 Hz), 7.80 (1H, d, J=6.8 Hz), 7.60 (1H, br.), 7.22 (1H, t, J=7.1 Hz), 6.52 (1H, s), 6.02 (1H, s), 4.74 (1H, s), 4.62 (1H, s), 4.51 (1H, m), 3.51 (3H, s), 1.45 (6H, s), 1.38 (3H, d, J=5.9 Hz). m/z (ESI, +ve) 383.9 (M+H)+.

Provenance & Evidence