(R)-6-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one → HCID 89783643, compound

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Reaction Steps

This compound (73 mg, 57% yield) as a tan amorphous solid was prepared according to the procedure described for Example 448, using 2-(tert-butylamino)-3-cyclopropyl-8-iodoquinazolin-4(3H)-one (718) (125 mg, 0.32 mmol) and (R)-6-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one (705) (85 mg, 0.32 mmol) as the starting materials. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.99 (1H, br. s.), 7.89 (1H, d, J=7.4 Hz), 7.85 (1H, d, J=7.8 Hz), 7.65 (1H, s), 7.16 (1H, t, J=7.7 Hz), 6.74 (1H, s), 6.15 (1H, s), 4.48-4.59 (1H, m), 2.88 (1H, br. s.), 1.54 (9H, s), 1.38 (3H, d, J=6.5 Hz), 1.27 (2H, d, J=6.7 Hz), 0.78 (2H, br. s.). m/z (ESI, +ve) 392.0 (M+H)+.

Provenance & Evidence