2,2,2-Trifluoroethylamine hydrochloride → HCID 89782000, compound

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Reaction Steps

2-Amino-3-bromo-N-(2,2,2-trifluoroethyl)benzamide (501a) (1.67 g, 81%) was prepared according to the procedures described for 720 using (2-amino-3-bromo-benzoic acid (1.5 g, 6.94 mmol, Sigma Aldrich), 2,2,2-trifluoroethylamine hydrochloride (1.1 g, 8.33 mmol, TCI), and DIEA (2.9 mL, 16.66 mmol, Sigma Aldrich) as the reagents. 1H NMR (400 MHz, DMSO-d6) δ ppm 9.00 (1H, t, J=6.16 Hz) 7.52-7.63 (2H, m) 6.57 (1H, t, J=7.82 Hz) 6.48 (1H, s) 4.05 (2H, qd, J=9.75, 6.36 Hz). m/z (ESI, +ve) 298.9/300.9 (M+H)+.

Provenance & Evidence