Triphosgene → HCID 89783877, compound

Participants

Reaction Steps

8-Bromo-3-(2,2,2-trifluoroethyl)quinazoline-2,4(1H,3H)-dione (501b, 1.53 g, 88%) was prepared according to the procedures described for 720 using 2-amino-3-bromo-N-(2,2,2-trifluoroethyl)benzamide (1.6 g, 5.39 mmol, 501a) and tri-phosgene (0.5 g, 1.777 mmol, Sigma Aldrich) as the reagents. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.86 (1H, s) 8.01 (2H, d, J=7.82 Hz) 7.20 (1H, t, J=7.82 Hz) 4.73 (2H, q, J=9.19 Hz). m/z (ESI, +ve) 322.9/324.9 (M+H)+.

Provenance & Evidence