Tert-Butylamine → HCID 89782230, compound

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8-Bromo-2-(tert-butylamino)-3-(2,2,2-trifluoroethyl)quinazolin-4(3H)-one (501d, 505 mg, 86%) as an off-white solid was prepared according to the procedures described for 408 using 8-bromo-2-chloro-3-(2,2,2-trifluoroethyl)quinazolin-4(3H)-one (534 mg, 1.562 mmol, 501c), tert-butylamine (4.9 mL, 46.9 mmol), and NMP (0.5 mL). 1H NMR (400 MHz, DMSO-d6) δ ppm 7.87-8.00 (2H, m) 7.06 (1H, t, J=7.73 Hz) 6.44 (1H, s) 5.22 (2H, q, J=9.00 Hz) 1.55 (9H, s). m/z (ESI, +ve) 379.9/381.0 (M+H)+.

Provenance & Evidence