Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Conditions

Reaction Steps

An orange solution of (R)-tert-butyl 2-(1-((tert-butoxycarbonyl)amino)propyl)-1-tosyl-1H-pyrrole-3-carboxylate (505c, 6.19 g, 12.93 mmol) in DCM (15 mL) was treated with TFA (15 mL, 202 mmol) and heated at 40° C. for 4 h. The TFA and DCM was removed in vacuo affording (R)-2-(1-aminopropyl)-1-tosyl-1H-pyrrole-3-carboxylic acid compound with TFA (1:1) as a viscous orange oil (505d) which was used the next step without further purification. m/z (ESI, +ve) 323.1 (M+1)′.

Provenance & Evidence