Diethylene Glycol → HCID 59411746, compound

Participants

Reaction Steps

The above procedure was carried out using the following quantities: 1-bromobutan-4-ol (1.70 g, 11.1 mmol), NMO (1.47 g, 12.1 mmol), molecular sieves (3.30 g), dichloromethane (45 mL), TPAP (0.39 g, 1.11 mmol); diethylene glycol (3.99 mL, 44.4 mmol), p-toluenesulfonic acid monohydrate (0.64 g, 3.35 mmol), molecular sieves (4.40 g) and dichloromethane (50 mL). Purification by chromatography on neutral alumina (gradient; dichloromethane to 2% methanol in dichloromethane) afforded the titled compound as a pale yellow oil (0.68 g, 40%).

Provenance & Evidence