Diethylene Glycol → HCID 59411765, compound

Participants

Reaction Steps

The above procedure was carried out using the following quantities: 1-bromohexan-6-ol (1.76 g, 10.3 mmol), NMO (1.33 g, 11.3 mmol), molecular sieves (3.0 g), dichloromethane (40 mL), TPAP (0.37 g, 1.03 mmol); diethylene glycol (4.63 mL, 51.5 mmol), p-toluenesulfonic acid monohydrate (0.59 g, 3.90 mmol), molecular sieves (4.0 g) and dichloromethane (50 mL). Purification by flash chromatography on silica (gradient; dichloromethane to 5% methanol in dichlorometane) afforded the titled compound as a pale yellow oil (0.45 g, 12%).

Provenance & Evidence