Diethylene Glycol → HCID 59411758, compound

Participants

Reaction Steps

The above procedure was carried out using the following quantities: 1-bromooctan-8-ol (2 g, 9.57 mmol), NMO (1.12 g, 9.57 mmol), molecular sieves (3.0 g), dichloromethane (40 mL), TPAP (0.34 g, 0.96 mmol); diethylene glycol (5.18 mL, 57.6 mmol), p-toluenesulfonic acid monohydrate (0.55 g, 2.91 mmol), molecular sieves (4.0 g) and dichloromethane (40 mL). Purification by flash chromatography on silica (gradient; dichloromethane to 3% methanol in dichlorometane) afforded the titled compound as colourless oil (1.50 g, 39%).

Provenance & Evidence