HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chlorophenyl)(phenyl)methanamine → (4-Chlorophenyl)(phenyl)methanamine, (S)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chlorophenyl)(phenyl)methanamine | HCID 409810 | — |
| Reactant | D-Tartaric acid | HCID 439655 | — |
| Product | (4-Chlorophenyl)(phenyl)methanamine, (S)- | HCID 736032 | — |
Reaction Steps
The racemic 4-chlorobenzhydrylamine was treated with D-tartaric acid, and then sequentially recrystallized ten times from water (as described by Clemo, et al., J. Chem. Soc., (1939), 1958-1960) to provide (S)-4-chlorobenzhydrylamine of high optical purity (ee>98%, according to chiral HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09399032B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-5c7d83a10736459f804e1b03d1c4e82d |
| Source note | uspto-grants-2016_07 |